The first edition published in received good reviews on Amazon four stars based on 5 reviews. Hence I had expected a book which provided a broad introduction to bioinformatics as applied to biology and medicine; however I regret to say I was disappointed. This book is divided into 5 chapters. The first chapter 'Biology and Information' begins with an interesting but lengthy and somewhat unfocused introduction to the application of computers in biology and medicine. This is followed by a useful and concise section in basic DNA and protein biochemistry, structure and function.
Databases are central to bioinformatics and chapter 2 on 'Biological Databases' should have provided a useful resource to novices to the field, however this chapter has been haphazardly updated from the first edition.
Many details in this chapter are out of date. In other instances statistics on the number of entries in a database are given, however a date or release version is not provided, thus making this information meaningless. This results in a chapter with poor layout and repetition. This layout is unsatisfactory also as it tends to focus on older databases ignoring valuable recent resources.
It is a pity that the authors did not direct the reader to the annual Nucleic Acids Research Database and Web Server issues. Major themes central to Bioinformatics such as multiple alignment and phylogenetic tree analysis are poorly addressed. With increasing numbers of complete genomes available, a more comprehensive introduction to phylogenetic analysis and comparative genomics would be valuable.
A highlight of the book is the well written and informative section on microarrays which was contributed by Thorsten Forster and Peter Ghazal in Chapter 3.
Unfortunately this did not include examples of applications of microarrays to biological science or medicine. Chapter 4 which focuses on proteome analysis contained sections on 2D gels, protein-protein interaction data, protein structure PDB and homology modeling of protein structure. The latter focused almost exclusively commercial software from Accelrys.
A large proportion of this chapter 30 pages was devoted to a detailed description of analytical ultracentrifugation and hydrodynamics.
Publication Type. More Filters. Issues in Comparative Fungal Genomics. Cell is the basic functional unit in the body. There are about different specialized types of cells in human body, although each is genetically the same. Yet, they are different in size, shape … Expand. Cell Content and Basic Construction.
Local sequence alignments statistics: deviations from Gumbel statistics in the rare-event tail. Mathematics, Computer Science. Algorithms Mol. Bacteria classification based on 16S ribosomal gene using artificial neural networks. CI Related Papers.
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